Table 1. Pathway analysis of DE genes in the RS (4060) cell line 4 and 24 h after 2 Gy irradiation.
| Pathway | P valuea | Number of genes | Gene list |
|---|---|---|---|
| Up-regulated | |||
| 4 h | |||
| direct p53 effectors | 7.79E-21 | 19 | BBC3, C12orf5, CDKN1A, DDB2, EPHA2, FAS, FDXR, GADD45A, GDF15, LIF, MDM2, PLK3, PRKAB1, RPS27L, RRM2B, SESN1, TNFRSF10B, TNFRSF10D, TRIAP1 |
| DNA damage response | 4.66E-09 | 9 | BBC3, CDKN1A, DDB2, FAS, GADD45A, MDM2, RRM2B, SESN1, TNFRSF10B |
| 24 h | |||
| direct p53 effectors | 1.21E-12 | 12 | C12orf5, CDKN1A, FDXR, LIF, MDM2, RPS27L, RRM2B, SESN1, TNFRSF10D, TP53I3, TRIAP1, ZNF385A |
| DNA damage response | 6.82E-03 | 4 | CDKN1A, MDM2, RRM2B, SESN1 |
| Down-regulated | |||
| 4 h | |||
| PLK1 signaling events | 1.31E-08 | 5 | AURKA, CCNB1, CDC20, KIF20A, PLK1 |
| regulation of mitotic cell cycle | 1.37E-05 | 4 | AURKA, CCNB1, CDC20, PLK1 |
ap values were corrected for multiple comparisons using the FDR (B&H).