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. 2016 Jun 1;6:26894. doi: 10.1038/srep26894

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The synthesized compounds differed in the highlighted part of the molecule, changed residue indicated with arrow. Compound 16-19 compound was synthesized to incorporate two modifications from two compounds, 16-8 and 16-18, found most potent in anti-TRPV4 screening assays (see Fig. 2).