Figure 6. Sivelestat specifically reduces tissue swelling in a post-surgically induced lymphoedema model.

(A) Dose–response effect of sivelestat on tail-volume increase after induction of surgical lymphoedema. Three mice per group were subjected to local treatment. PBS (indicated as ‘0 mg/kg’) was used as control ‘treatment’. (B–D) Sivelestat, but not GM6001, already significantly reduced the extent of swelling in WT mice from the first days after injury. The vehicle DMSO was used as a control for GM6001. (E) Sivelestat had no effect when locally injected in Emilin1^−/− mice. The numbers of mice used in (D) and (E) are reported in parentheses. Data are expressed as means±S.E.M.s.