Table 4.
Colorectal cancer (CRC)-specific survival at 10 years by age and molecular factor
| Molecular Factor | Model | Age group | Class | P-within age strata | P-interaction | |
|---|---|---|---|---|---|---|
|
| ||||||
| MSI | Low/MSS | High | ||||
|
| ||||||
| Event/N | <60 years | 56/192 | 2/18 | |||
| 60–74 years | 179/590 | 17/126 | ||||
| 75+ years | 75/238 | 3/48 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.36 (0.09 to 1.49) | 0.16 | 0.11 | |
| 60–74 years | 1 (Referent) | 0.42 (0.26 to 0.69) | 0.0007 | |||
| 75+ years | 1 (Referent) | 0.16 (0.05 to 0.52) | 0.002 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.47 (0.11 to 1.97) | 0.30 | 0.17 | |
| 60–74 years | 1 (Referent) | 0.42 (0.24 to 0.72) | 0.002 | |||
| 75+ years | 1 (Referent) | 0.18 (0.06 to 0.58) | 0.004 | |||
|
| ||||||
| CIMP | Low/negative | High | ||||
|
| ||||||
| Event/N | <60 years | 55/202 | 2/11 | |||
| 60–74 years | 164/566 | 29/136 | ||||
| 75+ years | 64/203 | 10/55 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.67 (0.16 to 2.74) | 0.58 | 0.21 | |
| 60–74 years | 1 (Referent) | 0.75 (0.50 to 1.11) | 0.15 | |||
| 75+ years | 1 (Referent) | 0.52 (0.27 to 1.01) | 0.06 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.37 (0.09 to 1.59) | 0.18 | 0.92 | |
| 60–74 years | 1 (Referent) | 0.89 (0.53 to 1.48) | 0.65 | |||
| 75+ years | 1 (Referent) | 0.68 (0.32 to 1.44) | 0.32 | |||
|
| ||||||
| KRAS | Wild-type | Mutant | ||||
|
| ||||||
| Event/N | <60 years | 34/133 | 24/81 | |||
| 60–74 years | 109/446 | 88/280 | ||||
| 75+ years | 41/168 | 39/122 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 1.21 (0.72 to 2.04) | 0.47 | 0.80 | |
| 60–74 years | 1 (Referent) | 1.30 (0.98 to 1.73) | 0.07 | |||
| 75+ years | 1 (Referent) | 1.36 (0.88 to 2.11) | 0.17 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 1.12 (0.64 to 1.94) | 0.70 | 0.89 | |
| 60–74 years | 1 (Referent) | 0.96 (0.71 to 1.29) | 0.78 | |||
| 75+ years | 1 (Referent) | 1.02 (0.64 to 1.61) | 0.94 | |||
|
| ||||||
| BRAF | Wild-type | Mutant | ||||
|
| ||||||
| Event/N | <60 years | 53/194 | 5/21 | |||
| 60–74 years | 162/615 | 34/108 | ||||
| 75+ years | 72/248 | 8/44 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.92 (0.37 to 2.30) | 0.86 | 0.52 | |
| 60–74 years | 1 (Referent) | 1.36 (0.94 to 1.97) | 0.11 | |||
| 75+ years | 1 (Referent) | 0.58 (0.28 to 1.19) | 0.14 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.80 (0.31 to 2.07) | 0.65 | 0.25 | |
| 60–74 years | 1 (Referent) | 2.06 (1.31 to 3.23) | 0.002 | |||
| 75+ years | 1 (Referent) | 1.09 (0.49 to 2.43) | 0.83 | |||
|
| ||||||
| CTNNB1 (nuclear expression) | Negative | Positive | ||||
|
| ||||||
| Event/N | <60 years | 33/109 | 17/86 | |||
| 60–74 years | 95/308 | 60/256 | ||||
| 75+ years | 18/ 86 | 25/81 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.59 (0.33 to 1.06) | 0.08 | 0.03 | |
| 60–74 years | 1 (Referent) | 0.72 (0.52 to 0.99) | 0.04 | |||
| 75+ years | 1 (Referent) | 1.55 (0.85 to 2.85) | 0.15 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 0.64 (0.35 to 1.16) | 0.14 | 0.03 | |
| 60–74 years | 1 (Referent) | 0.69 (0.49 to 0.96) | 0.03 | |||
| 75+ years | 1 (Referent) | 1.67 (0.89 to 3.13) | 0.11 | |||
|
| ||||||
| PIK3CA | Wild-type | Mutant | ||||
|
| ||||||
| Event/N | <60 years | 44/160 | 9/27 | |||
| 60–74 years | 152/563 | 28/106 | ||||
| 75+ years | 63/228 | 12/51 | ||||
| Unadjusted, HR (95% CI) | <60 years | 1 (Referent) | 1.33 (0.65 to 2.71) | 0.44 | 0.25 | |
| 60–74 years | 1 (Referent) | 0.98 (0.65 to 1.46) | 0.92 | |||
| 75+ years | 1 (Referent) | 0.80 (0.43 to 1.48) | 0.48 | |||
| Adjusted, HR (95% CI) | <60 years | 1 (Referent) | 1.42 (0.68 to 2.95) | 0.35 | 0.24 | |
| 60–74 years | 1 (Referent) | 0.88 (0.58 to 1.33) | 0.54 | |||
| 75+ years | 1 (Referent) | 0.72 (0.38 to 1.36) | 0.31 | |||
Abbreviations: HR, hazard ratio; CI, confidence interval; CIMP, CpG island methylator phenotype; MSI, microsatellite instability; MSS, microsatellite stable.