Table I.
Enriched GO categories and KEGG pathway enrichment analysis of DEGs in glioblastoma-associated stromal cells.
| A, KEGG analysis of upregulated DEGs. | ||||
|---|---|---|---|---|
| Category | Term | Biological process | Count | P-value |
| KEGG | 4110 | Cell cycle | 124 | 0 |
| KEGG | 3030 | DNA replication | 36 | 3.47×10−13 |
| KEGG | 4114 | Oocyte meiosis | 112 | 5.49×10−10 |
| KEGG | 4914 | Progesterone-mediated oocyte maturation | 86 | 2.10×10−7 |
| KEGG | 4115 | p53 signaling pathway | 68 | 2.13×10−6 |
| KEGG | 3430 | Mismatch repair | 23 | 5.90×10−4 |
| KEGG | 240 | Pyrimidine metabolism | 99 | 1.57×10−3 |
| KEGG | 3410 | Base excision repair | 33 | 2.39×10−3 |
| KEGG | 3420 | Nucleotide excision repair | 44 | 6.85×10−3 |
| KEGG | 3440 | Homologous recombination | 28 | 1.22×10−2 |
| B, KEGG analysis of downregulated DEGs. | ||||
| Category | Term | Biological process | Count | P-value |
| KEGG | 4920 | Adipocytokine signaling pathway | 68 | 3.85×10−3 |
| KEGG | 4960 | Aldosterone-regulated sodium reabsorption | 42 | 7.26×10−3 |
| KEGG | 4621 | NOD-like receptor signaling pathway | 58 | 1.75×10−2 |
| KEGG | 4964 | Proximal tubule bicarbonate reclamation | 23 | 1.99×10−2 |
| KEGG | 640 | Propanoate metabolism | 32 | 3.69×10−2 |
| KEGG | 4060 | Cytokine-cytokine receptor interaction | 265 | 3.93×10−2 |
| C, GO analysis of upregulated DEGs. | ||||
| Category | Term | Biological process | Count | P-value |
| BP | GO:0000070 | Mitotic sister chromatid segregation | 53 | 0 |
| BP | GO:0000075 | Cell cycle checkpoint | 226 | 0 |
| BP | GO:0000226 | Microtubule cytoskeleton organization | 297 | 0 |
| BP | GO:0000278 | Mitotic cell cycle | 816 | 0 |
| BP | GO:0000280 | Nuclear division | 346 | 0 |
| BP | GO:0000819 | Sister chromatid segregation | 56 | 0 |
| BP | GO:0006259 | DNA metabolic process | 896 | 0 |
| BP | GO:0006260 | DNA replication | 277 | 0 |
| BP | GO:0006261 | DNA-dependent DNA replication | 100 | 0 |
| BP | GO:0006270 | DNA replication initiation | 29 | 0 |
| D, GO analysis of downregulated DEGs. | ||||
| Category | Term | Biological process | Count | P-value |
| BP | GO:0008217 | Reg. of blood pressure | 147 | 9.85×10−6 |
| BP | GO:0045776 | Negative regulation of blood pressure | 35 | 3.08×10−4 |
| BP | GO:0071260 | Cellular response to mechanical stimulus | 57 | 1.98×10−3 |
| BP | GO:0035094 | Response to nicotine | 31 | 2.98×10−3 |
| BP | GO:0016486 | Peptide hormone processing | 32 | 3.27×10−3 |
| BP | GO:0002864 | Reg. of acute inflammatory response to antigenic stimulus | 10 | 3.73×10−3 |
| BP | GO:0031272 | Reg. of pseudopodium assembly | 10 | 3.73×10−3 |
| BP | GO:0016485 | Protein processing | 160 | 3.95×10−3 |
| BP | GO:0051239 | Reg. of multicellular organismal processes | 1963 | 4.20×10−3 |
| BP | GO:0006952 | Defense response | 1372 | 4.25×10−3 |
GO, gene ontology; DEG, differentially expressed gene; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes; Reg., regulation.