Table II.
Functional annotation of differentially expressed genes in glioblastoma-associated stromal cells.
| Category | n | Gene |
|---|---|---|
| Upregulated | ||
| TF | 11 | BRCA1, BRIP1, CDK2, HEYL, HMGB2, IRX5, MEF2C, MEIS2, MYBL2, RBL1, TBX2 |
| TAG oncogene | 9 | CCNA2, CCND2, CEP55, DUSP26, FGF5, HGF, MYBL2, NET1, PTTG1 |
| TAG tumor suppressor | 23 | AKAP12, BARD1, BLM, BMP2, BRCA1, BUB1B, CDH13, CHEK1, DAB2IP, E2F1, FANCD2, ID4, ITGB3, LIMD1, LIN9, MFSD2A, PCDH10, PTPN3, RBL1, STARD13, TFPI2, TMEFF2, ZFHX3 |
| Downregulated | ||
| TF | 6 | ARNT2, DDIT3, HES2, MITF, NFIA, NR3C2 |
| TAG oncogene | 3 | ARHGEF5, DDIT3, MRAS |
| TAG tumor suppressor | 10 | ATP8A2, BHLHE41, CABLES1, CDH4, DAB2, HRASLS2, LGI1, PLA2G16, RARRES3, RPS6KA2 |
TF, transcription factor; TAG, tumor-associated genes. BRCA1, breast cancer 1, early onset; BRIP1, BRCA1 interacting protein C-terminal helicase 1; CDK2, cyclin-dependent kinase 2; HEYL, hes-related family bHLH transcription factor with YRPW motif-like; HMGB2, high mobility group box 2; IRX5, iroquois homeobox 5; MEF2C, myocyte enhancer factor 2C; MEIS2, Meis homeobox 2; MYBL2, v-myb avian myeloblastosis viral oncogene homolog-like 2; RBL1, retinoblastoma-like 1; TBX2, T-box 2; CCNA2, cyclin A2; CCND2, cyclin D2; CEP55, centrosomal protein 55kDa; DUSP26, dual specificity phosphatase 26 (putative); FGF5, fibroblast growth factor 5; HGF, hepatocyte growth factor; NET1, neuroepithelial cell transforming 1; PTTG1, pituitary tumor-transforming 1; AKAP12, a kinase anchor protein; BARD1, BRCA1 associated RING domain 1; BLM, Bloom syndrome RecQ like helicase; BMP2, bone morphogenetic protein 2; BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CDH13, cadherin 13; CHEK1, checkpoint kinase 1; DAB2IP, DAB2 interacting protein; E2F1, E2F transcription factor 1; FANCD2, Fanconi anemia complementation group D2; ID4, inhibitor of DNA binding 4, dominant negative helix-loop-helix protein; ITGB3, integrin subunit beta 3; LIMD1, LIM domains containing 1; LIN9, lin-9 DREAM MuvB core complex component; MFSD2A, major facilitator superfamily domain containing 2A; PCDH10, protocadherin 10; PTPN3, protein tyrosine phosphatase, non-receptor type 3; STARD13, StAR related lipid transfer domain containing 13; TFPI2, tissue factor pathway inhibitor 2; TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2; ZFHX3, zinc finger homeobox 3; ARNT2, ary-hydrocarbon receptor nuclear translocator 2; DDIT3, DNA damage inducible transcript 3; HES2, hairy and enhancer of split 2; MITF, microphthalmia-associated transcription factor; NFIA, nuclear factor I/A; NR3C2, nuclear receptor subfamily 3 group C member 2; ARHGEF5, Rho guanine nucleotide exchange factor 5; MRAS, muscle RAS oncogene homolog; ATP8A2, ATPase, aminophospholipid transporter, class I, type 8A, member 2; BHLHE41, basic helix-loop-helix family member e41; CABLES1, Cdk5 and Abl enzyme substrate 1; CDH4, cadherin 4, type 1, R-cadherin; DAB2, Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila); HRASLS2, HRAS like suppressor 2; LGI1, leucine-rich, glioma inactivated 1; PLA2G16, phospholipase A2 group XVI; RARRES3, retinoic acid receptor responder (tazarotene induced) 3; RPS6KA2, ribosomal protein S6 kinase, 90kDa, polypeptide 2.