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. 2016 Jun 1;16:345. doi: 10.1186/s12885-016-2377-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — 3D culture attenuates the therapeutic response of ER + Her2+ cells. BT474 (a) and MDAMB361 (b) cells were grown for 10 days as 2D monolayers or as 3D cultures in Matrigel and their proliferative response to trastuzumab and endocrine monotherapy or their combination assessed using coulter counting. The growth inhibitory effects of trastuzumab and endocrine therapy on day 10, either as single agents or in combination, were significantly attenuated in 3D vs. 2D cultures. * p < 0.05, ** p < 0.001. t-test. C = control, H = trastuzumab (Herceptin), T = tamoxifen, F = fulvestrant