Inhibition of sphere formation by AKBA, α-BA or β-BA. ZH-161 (10,000 cells/well) were exposed to AKBA (19.5 µM), α-BA (22.0 µM) or β-BA (22.0 µM) and monitored for 168 h for sphere formation by phase contrast microscopy. Ethanol (1%) was included as solvent control. BA, boswellic acid; AKBA, acetyl-11-keto-β-boswellic acid.