Skip to main content
. 2016 May 26;4:e2081. doi: 10.7717/peerj.2081

Figure 3. P-gp or Bcrp knockout did not alter CBD brain/plasma concentration ratios, whilst P-gp knockout profoundly increased risperidone and 9-hydroxy risperidone brain/plasma ratios.

Figure 3

(A) CBD brain/plasma concentration ratios (B) risperidone brain/plasma concentration ratios (C) 9-hydroxy risperidone brain/plasma concentration ratios. CBD, cannabidiol; 9-OH risperidone, 9-hydroxy risperidone; WT, wild-type; P-gp, Abcb1a/b(−∕−) (P-gp knockout); Bcrp, Abcg2(−∕−) (Bcrp knockout); P-gp/Bcrp, Abcb1a/b(−∕−)Abcg(−∕−) (P-gp/Bcrp combined knockout). Tukey post-hoc analyses, ∗p < 0.05 for comparisons between WT and knockout mice. Data represent mean + S.E.M.