Table 1.
Patient baseline characteristics
| Patient no. | Sex F/M | Age (years) | FEV1 in L (% pred) | Kco (% pred) | Perc15 (HU) | Weight (kg) | Length (m) |
|---|---|---|---|---|---|---|---|
| 1 | F | 48 | 0.62 (22) | 32 | −945 | 77 | 1.68 |
| 2 | F | 43 | 0.82 (35) | 41 | −970 | 51 | 1.52 |
| 3 | F | 49 | 1.21 (38) | 37 | −970 | 59 | 1.67 |
| 4 | M | 65 | 1.21 (40) | 42 | −953 | 85 | 1.71 |
| 5 | M | 58 | 1.20 (38) | 39 | −962 | 62 | 1.70 |
| 6 | F | 56 | 0.94 (30) | 36 | −967 | 75 | 1.62 |
| 7 | F | 61 | 0.45 (20) | — | −987 | 56 | 1.66 |
| 8 | M | 53 | 1.22 (40) | 41 | −973 | 74 | 1.71 |
| 9 | F | 51 | 0.96 (39) | 57 | −933 | 59 | 1.61 |
| 10 | M | 55 | 0.58 (16) | — | −988 | 65 | 1.78 |
Patient 5 was of Asian race, all others were Caucasian. In patient 7 and 10 only multiple breath analysis for gas transfer could be performed; Perc15 is CT-based lung density value of both lungs at the 15th percentile point, expressed in Hounsefield Units (HU). During the screening of patients who volunteered for the study we noticed that the inclusion of subjects who had emphysema equally distributed in the upper lung lobes was rather rare. For the histopathological analysis, we reasoned that equal distribution was of prime importance. This was the reason why the ethical board allowed higher Kco values coinciding with equally distributed emphysema calculated by CT scan-derived lung densitometry.