Table 1.
Summary of effects of TLR stimulation on BMDMs
| TLR7 | TLR9 | TLR4 | TLR3 | |
|---|---|---|---|---|
| Location | Endosomal | Endosomal | Surface | Endosomal |
| Signaling | MyD88 | MyD88 | MyD88/TRIF | TRIF |
| Effects on BMDMs | ||||
| Survival | ↑ | ↑ | ↑ | Unchanged |
| Phagocytosis | ↑ | ↑ | ↑ | ↑ |
| Co-stimulatory molecules | ↓MHCII, ↓CD86, ↑CD40 | ↓MHCII, ↓CD86, ↑CD40 | ↑CD86, ↑CD80, ↑CD40 | ↑CD86, ↑MHCII, ↑CD40 |
| Antigen presentation | ↓ | ↓ | ↑ | ↑ |
| Cytokine production | ↑TNFα, ↑IL-6, ↑IL-10 | ↑TNFα, ↑IL-6, ↑IL-10 | ↑TNFα, ↑IL-6, ↑IL-10 | Unchanged |
| IL-12/IL-10 ratio | ↓ | ↓ | Unchanged | ND |
↑, increased; ↓, decreased; ND, not defined.