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Gal-1 modulates CAF-augmented MDA-MB-231 cell migration and invasion by upregulating MMP-9 expression (A) The levels of secreted MMP-9 protein in the medium were determined by human MMP-9 ELISA kit. (B,C) Inhibition of MMP-9 activity significantly reduced CAF/Con-CM and NF/OE-CM-induced cell migration and invasion. All data were expressed as mean ± SD of three experiments. **P< 0.01 vs. NF/Con-CM; ##P< 0.01 vs. CAF/Con-CM. Con, controls; OE, overexpressions; KD, knockdowns.
