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The changes of one-carbon metabolism pathway at three time points Diversion of cysteine to taurine and 5-methyl THF were followed by decreases at ATO treatment with an increase in transmethylation, transsulfuration, and methionine salvage. Metabolites with changed level are highlighted in blue, coupled with line chart nearby. The down trends are shown with green arrow, respectively. *P< 0.05. SAM, S-adenosyl methionine; SAH, S-adenosyl-l-homocysteine; THF, tetrahydrofuran.
