Figure 3.

SSTF treatment reduced tau phosphorylation in the VaD rat brain Representative immunoblots for the expression of tau and phosphorylated tau in the cortex (A) and hippocampus (B). Sixty days of SSTF (100 mg/kg) treatment did not alter the total tau (C), but significantly reduced levels of phosphorylated tau at sites Ser199 (D), Ser202 (E), Thr205 (F), Ser396 (G), and Ser404 (H) in the cortex and hippocampus. The total tau or phosphorylated tau was normalized to either GAPDH or total tau, respectively. The relative levels of total tau or phosphorylated tau of sham group were set at 100%. Data are shown as the mean ± SEM (n = 9). *P < 0.05 and **P < 0.01.