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. 2015 Sep 9;71(6):703–712. doi: 10.1093/gerona/glv141

Figure 4.

Figure 4.

Associations between PRS and longevity. Overall, the weighted PRS was found to be fairly evenly distributed and ranged between −3.68 and 6.02 (a). When comparing the scores of our GWAS cases and controls, we found that there was no overlap between the two groups (b)—cases all had scores of 2.34 or greater (with a mean of 4.17), while controls had scores ranging between −3.41 and 2.32 (with a mean of −0.55). A multinomial logistic regression model was used to examining the association between PRS and age in a validation sample (n = 6,447). Results were used to predict the proportion of centenarians in the population by PRS (c). We found that among individuals with a PRS of −2.0 (2 SDs below the mean), only 3.2 in 100,000 persons are predicted to be a centenarian. On the other hand, for individuals with a PRS of 2.0 (2 SDs above the mean), 340.3 in 100,000 persons are predicted to become centenarians. GWAS = genome-wide association study; PRS = polygenetic risk score; SNP = single nucleotide polymorphism.