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. 2015 Oct 8;71(6):730–739. doi: 10.1093/gerona/glv175

Figure 1.

Figure 1.

Expression and activity of sirtuin 1 (SIRT1). Resveratrol increased the protein level of SIRT1 in doxorubicin-treated, aged skeletal muscle (A). Doxorubicin suppressed SIRT1 activity in the skeletal muscle of both age groups, but the activity of SIRT1 was restored in response to resveratrol treatment (B). $ p < .05, aging effect; *p < .05, doxorubicin effect; # p < .05, resveratrol effect; + p < .05, inhibitor effect; ^p < .05, aging effect within treatment group. Mice were randomly assigned to saline control (SC), doxorubicin and vehicle (DV), and doxorubicin and resveratrol (DR) with sirtinol (DRS) or EX527 (DRE) groups.