Table 3.

Baseline MRI Volumes Categorized by Albuminuria Status and eGFR

Variable	No ALB at Baseline		ALB at Baseline
	eGFR ≥ 90	eGFR < 90	eGFR ≥ 90	eGFR < 90	Interaction‡
	n = 174	n = 180	n = 56	n = 87
Model I
Baseline total AWMV	1.42 (0.29)	2.13 (0.28)	1.97 (0.51)	3.40 (0.41)*	.51
Baseline TBV	931.4 (7.2)	912.1 (7.1)	945.6 (12.8)	930.2 (10.2)	.84
Baseline GMV	468.2 (3.7)	460.9 (3.6)	469.7 (6.5)	461.3 (5.2)	.91
Model II
Baseline total AWMV	1.43 (0.29)	2.31 (0.28)*	1.82 (0.50)	3.05 (0.41)	.65
Baseline TBV	931.4 (7.2)	908.7 (7.2)*	948.2 (12.8)	934.4 (10.5)	.65
Baseline GMV	468.1 (3.7)	469.7 (3.7)	470.5 (6.5)	462.5 (5.3)	.97
Model III
Baseline total AWMV	1.71 (0.28)	2.17 (0.28)	2.04 (0.49)	2.64 (0.41)	.85
Baseline TBV	923.6 (2.0)	928.4 (2.0)	922.5 (3.4)†	925.9 (2.9)	.79
Baseline GMV	463.7 (2.0)	468.6 (2.0)	457.1 (3.6)†	463/5 (3.0)	.93
Model IV
Baseline total AWMV	1.78 (0.34)	2.20 (0.32)	2.03 (0.53)	2.44 (0.45)	.99
Baseline TBV	924.4 (2.4)	927.4 (2.3)	923.7 (3.8)	925.8 (3.2)	.86
Baseline GMV	463.5 (2.5)	467.2 (2.4)	458.7 (3.9)	467.1 (3.9)	.74
Duration of known DM (y)	9.9 (0.5)	8.7 (0.5)	11.1 (0.9)	12.3 (0.8)†

Notes: ALB = albuminuria; AWMV = abnormal white matter volume; CVD = cardiovascular disease; eGFR = estimated glomerular filtration rate; GMV = gray matter volume; SBP = systolic blood pressure; TBV = total brain volume.

Least square means (SE). Values are in cubic centimeters. Several baseline eGFR measures were missing leading to slight differences in numbers from Table 2.

Model I: unadjusted.

Model II: adjusted for SBP.

Model III: adjusted for SBP, age, sex, and intracranial volume.

Model IV: adjusted for terms in Model III plus diabetes duration, prevalent CVD, and baseline eGFR.

*eGFR < 90 significantly (p < .05) different than the eGFR ≥ 90 group for the same level of ALB status.

^†Any ALB different from No ALB (p < .05) at the same level of eGFR category.

^‡Interaction between presence of ALB and GFR ≥ 90 or < 90.