Table 4.
Change in MRI Volumes From Baseline to 40 Months Categorized by Albuminuria Status
| No Albuminuria | Persistent Albuminuria | Remitters | Progressors | |
|---|---|---|---|---|
| n = 298 (59.5%) | n = 79 (15.8%) | n = 64 (12.8%) | n = 60 (12.0%) | |
| Model I | ||||
| AWMV change | 1.29 (0.16) | 2.54 (0.31)* | 0.80 (0.34) | 2.02 (0.35) |
| TBV change | −14.0 (1.0) | −17.7 (1.9) | −17.5 (2.1) | −16.0 (2.1) |
| GMV change | −19.7 (1.1) | −17.0 (2.2) | −19.6 (2.4) | −21.8 (2.5) |
| Model II | ||||
| AWMV change | 1.30 (0.16) | 2.44 (0.31)* | 0.79 (0.34) | 2.02 (0.35) |
| TBV change | −13.7 (0.9) | −18.0 (1.8) | −17.4 (2.0) | −16.0 (2.1) |
| GMV change | −19.5 (1.1) | −17.1 (2.2) | −19.6 (2.4) | −21.8 (2.5) |
| Model III | ||||
| AWMV change | 1.36 (0.16) | 2.18 (0.32) | 0.82 (0.34) | 2.01 (0.35) |
| TBV change | −14.0 (0.9) | −16.4 (1.8) | −17.7 (2.0) | −16.1 (2.0) |
| GMV change | −19.8 (1.1) | −16.0 (2.3) | −20.1 (2.5) | −21.5 (2.5) |
| Model IV | ||||
| AWMV change | 1.41 (0.16) | 2.10 (0.32) | 0.77 (0.34) | 1.92 (0.35) |
| TBV change | −14.3 (0.9) | −15.9 (1.8) | −17.4 (2.0) | −15.6 (2.0) |
| GMV change | −20.1 (1.1) | −15.3 (2.3) | −20.1 (2.5) | −21.2 (2.5) |
| Model V | ||||
| AWMV change | 1.42 (0.16) | 2.04 (0.34) | 0.77 (0.35) | 1.95 (0.36) |
| TBV change | −14.4 (0.9) | −15.1 (1.9) | −17.1 (2.0) | −14.5 (2.0) |
| GMV change | −20.1 (1.1) | −14.0 (2.4) | −20.0 (2.5) | −20.6 (2.6) |
Notes: AWMV = abnormal white matter volume; CVD = cardiovascular disease; eGFR = estimated glomerular filtration rate; GMV = gray matter volume; SBP = systolic blood pressure; TBV = total brain volume.
Least square means (SE). Values are in cubic centimeters.
Model I: unadjusted.
Model II: adjusted for SBP.
Model III: adjusted for age, sex, SBP at baseline, treatment arms of ACCORD study (intensive vs standard glycemia, lipid, and blood pressure control), and intracranial volume.
Model IV: adjusted for terms in Model III plus diabetes duration, prevalent and incident CVD, baseline eGFR, and annual rate of eGFR change.
Model V: adjusted for terms in Model IV plus interaction term with baseline eGFR ≥ 90 vs eGFR < 90mL/min/1.73 m2.
*Significantly different from the No albuminuria group (p < .05).