Table 1.
In vitro susceptibilities of Candida species to antifungal agents determined by the broth microdilution method
| Species (number) and antifungals |
MIC range (µg/ml) |
MIC50
(µg/ml) |
MIC90
(µg/ml) |
S (%) | S-DD or I (%) |
R (%) |
|---|---|---|---|---|---|---|
| Candida spp. (200) | ||||||
| Amphotericin B | 0.06–2.0 | 0.12 | 0.5 | 100 | – | 0 |
| Fluconazole | 0.12– ≥ 64.0 | 0.25 | 1.0 | – | – | – |
| Voriconazole | ≤0.015–0.12 | 0.03 | 0.06 | – | – | – |
| Posaconazole | ≤0.015–0.12 | ≤0.015 | 0.06 | – | – | – |
| Caspofungin | ≤0.008–0.12 | 0.015 | 0.06 | – | – | – |
| Anidulafungin | ≤0.008–0.12 | 0.03 | 0.06 | – | – | – |
| C. albicans (95) | ||||||
| Amphotericin B | 0.12–1.0 | 0.12 | 0.25 | 100 | – | 0 |
| Fluconazole | 0.12–2.0 | 0.25 | 0.5 | 100 | 0 | 0 |
| Voriconazole | ≤0.015–0.06 | ≤0.015 | 0.03 | 100 | 0 | 0 |
| Posaconazole | ≤0.015–0.12 | ≤0.015 | 0.03 | 100 | 0 | 0 |
| Caspofungin | ≤0.008–0.12 | 0.015 | 0.06 | 100 | 0 | 0 |
| Anidulafungin | 0.015–0.12 | 0.015 | 0.03 | 100 | 0 | 0 |
| C. glabrata (36) | ||||||
| Amphotericin B | 0.06–1.0 | 0.12 | 0.5 | 100 | – | 0 |
| Fluconazole | 0.12– ≥ 64.0 | 1.0 | 4.0 | – | 97.2 | 2.8 |
| Voriconazole | ≤0.015–0.12 | 0.03 | 0.06 | – | – | – |
| Posaconazole | ≤0.015–0.12 | 0.06 | 0.12 | – | – | – |
| Caspofungin | ≤0.008–0.12 | 0.06 | 0.12 | 100 | 0 | 0 |
| Anidulafungin | 0.015–0.12 | 0.03 | 0.06 | 100 | 0 | 0 |
| C. parapsilosis (28) | ||||||
| Amphotericin B | 0.06–0.5 | 0.12 | 0.25 | 100 | – | 0 |
| Fluconazole | 0.12–0.5 | 0.12 | 0.5 | 100 | 0 | 0 |
| Voriconazole | ≤0.015–0.03 | ≤0.015 | 0.03 | 100 | 0 | 0 |
| Posaconazole | ≤0.015–0.03 | ≤0.015 | 0.03 | 100 | 0 | 0 |
| Caspofungin | 0.015–0.12 | 0.015 | 0.06 | 100 | 0 | 0 |
| Anidulafungin | 0.015–0.12 | 0.015 | 0.06 | 100 | 0 | 0 |
| C. tropicalis (24) | ||||||
| Amphotericin B | 0.12–0.5 | 0.25 | 0.5 | 100 | – | 0 |
| Fluconazole | 0.12–1.0 | 0.25 | 1.0 | 100 | 0 | 0 |
| Voriconazole | ≤0.015–0.06 | 0.03 | 0.06 | 100 | 0 | 0 |
| Posaconazole | ≤0.015–0.03 | ≤0.015 | 0.03 | 100 | 0 | 0 |
| Caspofungin | ≤0.008–0.06 | 0.015 | 0.06 | 100 | 0 | 0 |
| Anidulafungin | 0.015–0.06 | 0.03 | 0.06 | 100 | 0 | 0 |
| C. kefyr (10) | ||||||
| Amphotericin B | 0.12–2.0 | 0.5 | 2.0 | 70 | 0 | 30 |
| Fluconazole | 0.12–0.5 | 0.25 | 0.25 | – | – | – |
| Voriconazole | ≤0.015–0.03 | ≤0.015 | 0.03 | – | – | – |
| Posaconazole | ≤0.015–0.03 | ≤0.015 | 0.03 | – | – | – |
| Caspofungin | ≤0.008–0.03 | 0.015 | 0.03 | – | – | – |
| Anidulafungin | 0.015–0.12 | 0.03 | 0.06 | – | – | – |
| C. lusitaniae a (7) | ||||||
| Amphotericin B | 0.12–0.25 | – | – | – | ||
| Fluconazole | 0.12–1.0 | – | – | – | ||
| Voriconazole | ≤0.015–0.6 | – | – | – | ||
| Posaconazole | ≤0.015–0.6 | – | – | – | ||
| Caspofungin | ≤0.008–0.03 | – | – | – | ||
| Anidulafungin | 0.015–0.06 | – | – | – | ||
S susceptible; S-DD susceptible-dose dependent; I intermediate; R resistant
aA categorical evaluation was not performed because the number is smaller than ten