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. 2016 May 27;473(11):1537–1552. doi: 10.1042/BCJ20160024

Figure 9. mlt1Δ/Δ mutant shows attenuation in virulence.

Figure 9

(A) Killing assay for C. albicans WT (SC5314), mlt1Δ/Δ and mlt1Δ/Δ::MLT1 cells in human whole blood after 4 h showing higher tendency of killing by the mlt1Δ/Δ mutant. (B) Survival curve of mice infected with mlt1Δ/Δ mutant shows attenuation in virulence as the mice infected with mutant strains survived up to 11 days post-infection compared with the WT C. albicans strains where all of the mice succumbed to infection within 8 days. Virulence was partially restored when a single copy of the MLT1 gene was added back to mutants. p.i., post-infection.