Table 3.
Summary of meta-analysis outcomes for Japanese type 2 diabetes patients with low (<25 kg/m2) and high (≥25 kg/m2) baseline body mass index (BMI)
| Outcome | Effect estimate | 95 % Confidence limits | p value | Effect estimate | 95 % Confidence limits | p value | ||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| Low (<25 kg/m2) baseline BMI | High (≥25 kg/m2) baseline BMI | |||||||
| Change in HbA1c (%) | −0.88 | −1.21 | −0.55 | <0.0001 | −1.28 | −1.81 | −0.75 | <0.0001 |
| Change in weight (kg) | −0.38 | −1.07 | 0.32 | 0.29 | −0.28 | −1.18 | 0.61 | 0.53 |
| Change in FPG (mg/dL) | −5.9 | −19.1 | 7.5 | 0.39 | −21.2 | −45.8 | 3.5 | 0.09 |
| Change in PPG: meal: test (mg/dL) | −147.9 | −178.6 | −117.3 | <0.0001 | −151.5 | −178.8 | −124.3 | <0.0001 |
| Odds ratio | 95 % Confidence limits | p value | Odds ratio | 95 % Confidence limits | p value | |||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| Low (<25 kg/m2) baseline BMI | High (≥25 kg/m2) baseline BMI | |||||||
| Symptomatic hypoglycemia | 2.8 | 1.1 | 7.0 | 0.0270 | 4.2 | 1.1 | 15.7 | 0.0362 |
| Severe hypoglycemia | 0.0 | 0.0 | 0.0 | – | 0.0 | 0.0 | 0.0 | – |
| Endpoint HbA1c <7 % | 11.2 | 3.2 | 39.7 | 0.0002 | 23.6 | 3.0 | 183.6 | 0.0025 |
| Endpoint HbA1c <7 % and no weight gain | 7.6 | 2.1 | 27.9 | 0.0024 | 16.2 | 2.1 | 127.2 | 0.0083 |
| Endpoint HbA1c <7 % and no symptomatic hypoglycemia | 9.6 | 2.1 | 43.7 | 0.0036 | 15.6 | 2.0 | 123.7 | 0.0093 |
| Endpoint HbA1c <7 % and no weight gain and no symptomatic hypoglycemia | 7.4 | 1.6 | 32.2 | 0.0114 | 9.5 | 1.2 | 77.7 | 0.0356 |
FPG fasting plasma glucose, PPG postprandial glucose