Table 3.
Predictive performance of CRB-65, CRB and qSOFA
| 95 % CI | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Outcomes | Predictors | Cut-off value | Sensitivity | Specificity | PPV | NPV | LR+ | LR− | OR | 5 % | 95 % |
| Mortality | CRB-65 | ≤1 | 70 % | 57 % | 45 % | 79 % | 1.6 | 0.5 | 3.059 | 2.459 | 3.804 |
| CRB-65 | 2 | 30 % | 88 % | 55 % | 72 % | 2.5 | 0.8 | 3.120 | 2.409 | 4.041 | |
| CRB-65 | ≥3 | 7 % | 98 % | 60 % | 68 % | 3.5 | 1.0 | 3.141 | 1.854 | 5.321 | |
| CRB | ≤1 | 36 % | 81 % | 51 % | 70 % | 1.9 | 0.8 | 2.442 | 1.927 | 3.094 | |
| CRB | 2 | 9 % | 97 % | 62 % | 66 % | 3.0 | 0.9 | 3.201 | 1.994 | 5.139 | |
| qSOFA | ≤1 | 53 % | 75 % | 52 % | 76 % | 2.1 | 0.6 | 3.418 | 2.752 | 4.246 | |
| qSOFA | 2 | 12 % | 97 % | 68 % | 69 % | 4.0 | 0.9 | 4.783 | 3.063 | 7.469 | |
| Hospitalisation | CRB-65 | ≤1 | 59 % | 56 % | 60 % | 55 % | 1.3 | 0.7 | 1.807 | 1.485 | 2.198 |
| CRB-65 | 2 | 22 % | 86 % | 63 % | 50 % | 1.6 | 0.9 | 1.715 | 1.322 | 2.224 | |
| CRB-65 | ≥3 | 5 % | 97 % | 67 % | 48 % | 1.7 | 1.0 | 1.851 | 1.073 | 3.195 | |
| CRB | ≤1 | 27 % | 81 % | 62 % | 50 % | 1.4 | 0.9 | 1.630 | 1.290 | 2.060 | |
| CRB | 2 | 6 % | 97 % | 69 % | 48 % | 2.0 | 1.0 | 2.066 | 1.263 | 3.381 | |
| qSOFA | ≤1 | 42 % | 74 % | 64 % | 53 % | 1.6 | 0.8 | 2.006 | 1.627 | 2.473 | |
| qSOFA | 2 | 8 % | 97 % | 74 % | 49 % | 2.7 | 1.0 | 2.673 | 1.675 | 4.265 | |
| ICU admission | CRB-65 | ≤1 | 76 % | 53 % | 22 % | 93 % | 1.6 | 0.5 | 3.589 | 2.626 | 4.906 |
| CRB-65 | 2 | 38 % | 86 % | 32 % | 89 % | 2.7 | 0.7 | 3.611 | 2.681 | 4.864 | |
| CRB-65 | ≥3 | 14 % | 98 % | 57 % | 87 % | 7.0 | 0.9 | 8.444 | 4.967 | 14.357 | |
| CRB | ≤1 | 45 % | 81 % | 29 % | 89 % | 2.4 | 0.7 | 3.426 | 2.579 | 4.552 | |
| CRB | 2 | 15 % | 97 % | 49 % | 87 % | 5.0 | 0.9 | 6.352 | 3.970 | 10.163 | |
| qSOFA | ≤1 | 60 % | 70 % | 26 % | 91 % | 2.0 | 0.6 | 3.554 | 2.687 | 4.702 | |
| qSOFA | 2 | 18 % | 96 % | 45 % | 87 % | 4.5 | 0.9 | 5.471 | 3.558 | 8.411 | |
Abbreviations: qSOFA quick Sepsis-related Organ Failure Assessment, PPV positive predictive value, NPV negative predictive value, LR + positive likelihood ratio, LR − negative likelihood ratio, ICU intensive care unit, CRB confusion, respiratory rate ≥30/minute, systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg, CRB-65 confusion, respiratory rate ≥30/minute, systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg, age ≥65 years