Fig. 1.

Peripheral glucagon-like peptide-1 receptor (GLP-1R) signaling contributes to the improvements in glucose tolerance after Roux-en-Y gastric bypass (RYGB). A: blockade of GLP-1R by chronic exendin-(9–39) (Ex-9) infusion (2 pmol·kg⁻¹·min⁻¹) impaired oral glucose tolerance to a greater extent in RYGB vs. sham mice. B: area under the curve (AUC) calculations for glucose excursion curves after oral glucose administration are shown. Values represent means ± SE. **P < 0.01 and ***P < 0.001, significant differences in comparisons of Sham and RYGB groups treated with Vehicle and Ex-9; #P < 0.05, significant differences in comparisons of weight-matched sham (WMS) with sham and RYGB vehicle-treated groups.