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Chronic blockade of central GLP-1 signaling does not attenuate the improved glucose tolerance or weight loss after RYGB. Chronic blockade of central GLP-1R (0.5 pmol·kg−1·min−1) did not influence oral glucose tolerance (A and B) or oral glucose-stimulated insulin secretion (C and D). Weekly body weight over 4 wk (E) and fat mass after 8 wk (F) of chronic infusion was not altered by Ex-9. Values are means ± SE. *P < 0.05; ***P < 0.001.
