Table 2.
Partial correlations of relative normalized amount of each CHRN subunit gene mRNA expression levels with lung function parameters
| CHRNA3 | CHRNA4 | CHRNA5 | CHRNA6 | CHRNA7 | CHRNB2 | CHRNB3 | CHRNB4 | |
|---|---|---|---|---|---|---|---|---|
| FEV1 | 0.019 (P = 0.587) | 0.325* (P = 0.014*) | 0.338* (P = 0.010*) | −0.002 (P = 0.059) | 0.370* (P = 0.004*) | −0.061 (P = 0.302) | −0.108 (P = 0.833) | −0.053 (P = 0.263) |
| FEV1, % pred | 0.040 (P = 0.355) | 0.375* (P = 0.043*) | 0.403* (P = 0.011*) | −0.071 (P = 0.071) | 0.425* (P = 0.023*) | −0.080 (P = 0.456) | −0.181 (P = 0.111) | −0.126 (P = 0.112) |
| FVC | 0.038 (P = 0.217) | 0.485* (P = 0.041*) | 0.469* (P = 0.032*) | −0.144 (P = 0.231) | 0.471 (P = 0.054) | −0.179 (P = 0.125) | −0.050 (P = 0.542) | −0.061 (P = 0.255) |
| FVC, % pred | 0.086 (P = 0.116) | 0.593* (P = 0.021*) | 0.587* (P = 0.011*) | −0.033 (P = 0.067) | 0.576* (P = 0.013*) | −0.211 (P = 0.433) | −0.119 (P = 0.113) | −0.234 (P = 0.132) |
| FEV1/FVC | 0.154 (P = 0.213) | 0.037 (P = 0.313) | 0.056 (P = 0.543) | −0.120 (P = 0.121) | 0.076 (P = 0.073) | −0.419* (P = 0.043*) | −0.079 (P = 0.217) | −0.072 (P = 0.562) |
r values are shown correlating lung function parameters with quantitative expression of various nicotinic acetylcholine receptors (nAChRs). Significant P values (
*
P < 0.05) are underlined in bold.