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. 2016 Jun 1;10:38. doi: 10.1186/s12918-016-0281-4

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© Di Camillo et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The model of insulin signalling pathway. The model of Insulin Signaling Pathway obtained by integrating the PI3K-AKT pathway, the mTOR pathway and the RAS-MAPK pathway, depicted using the Systems Biology Graphical Notation. Coloured nodes resemble the clustering results obtained on simulated profiles (see Fig. 3). Coloured lines represent important feedback mechanisms; namely: the red line represents the P70S6K-IRS1 negative feedback loop, the blue line the ERK1/2-GRB2/SOS negative feedback loop