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. 2016 May 31;17:115. doi: 10.1186/s13059-016-0971-7

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© Bakker et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Karyotype heterogeneity of human B-ALLs increases upon engraftment into recipient mice. a Overview of B-ALL patient material used in this study. b Genome-wide copy number plots using ~1 Mb bins for bone marrow cells of three B-ALL patients. For B-ALL A and B, respectively, 8 and 3 euploid cells are present (non-cancer cells). c Genome-wide copy number plots using ~1 Mb bins for bone marrow cells of two mice, 28 weeks after engraftment with B-ALL B. d Aneuploidy and heterogeneity scores for the analysed B-ALL patient material and engraftments B-1 and B-2. The orange triangle indicates the baseline level of aneuploidy and heterogeneity of the near-euploid B-ALL A