Table 1.

Investigation and evaluation of three cases of primary ovarian insufficiency.

Laboratory findings	Case 1	Case 2	Case 3	Reference ranges (follicular phase)
FSH, first measurement (IU/mL)	85	142	56	3.5–12.5
FSH, second measurement (IU/mL)	77	103	51	3.5–12.5
LH (IU/mL)	37	73	41	2.4–12.6
Estradiol (pg/mL)	16	33	4.1	12.5–166.0
Prolactin (ng/mL)			6.0	6.0–29.9
TSH (mIU/mL)	2.3		0.73	0.27–4.2
Anti-TPO (IU/mL)	150		NR	<35.0
β-HCG (mIU/mL)	Negative	Negative	Negative	<5.0 (not pregnant)
Lupus anticoagulant	Nonreagent	Nonreagent	Nonreagent	NR
Antibody antinuclear	Negative	Negative	Negative	NR
Factor LE cell	Nonreagent	Nonreagent	Nonreagent	NR
Pelvic US
Uterine volume	45cm3	161 cm3	24.8cm3
Endometrial thickness	0.3cm	0.5 cm	0.3cm
Right ovary volume	2.6cm3	2.17 cm3	0.83cm3
Left ovary volume	3.5cm3	1.28 cm3	0.91cm3
DXA	Z score −1.0 (lumbar spine and total femur)	Z score −2.2 (lumbar spine) and −1.8 (neck of femur)	T score −3.3 (0.779g/cm2) in lumbar spine; −2.28 (0.733g/cm2) in total femur; −2.5 (0.691g/cm2) in neck of femur
Karyotype	46,XX	46,XX – positive for an expanded allele of FMR1 for fragile X syndrome (premutation)	46,XX

Anti-TPO, anti-thyroid peroxidase antibodies; DXA, dual-energy X-ray absorptiometry; FSH, follicle-stimulating hormone; HCG, human chorionic gonadotrophin; IU, international units; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; US, ultrasound.