. 2016 May 31;9:312. doi: 10.1186/s13071-016-1592-4

Table 2.

Antifilarial activity of crude extract of aerial parts of Taxodium distichum, its molecules, and the reference drugs ivermectin and DEC against Brugia malayi in jirds, Meriones unguiculatus (mean ± standard deviation)

Antifilarial agent	Dose mg/kg s.c. × 5 days (n)	Worms recovered			Sterilised female worm count (%)
Antifilarial agent	Dose mg/kg s.c. × 5 days (n)	Male	Female	Total (% reduction over untreated)
A001 (Crude extract)	500 p.o. (6)	0	0	0*** (5)	–2 (28.57)
A001 (Crude extract)	500 p.o. (6)	0	0	11.00 (1)^b	–2 (28.57)
K003	100 (5)	0.40 ± 0.89	8.00 ± 0.71	8.40 ± 1.14	8.00 ± 0.71
K003	100 (5)	0.40 ± 0.89	8.00 ± 0.71	(27.12)	(> 95)***
K004	100 (5)	0	8.00 ± 0.82	8.00 ± 0.82	1.50 ± 0.58
K004	100 (5)	0	8.00 ± 0.82	(32.20)	(18.85 ± 7.22)
Ivermectin^a	1 (4)	2.75 ± 0.96	6.25 ± 1.50	9.67 ± 2.52	2.75 ± 0.96
Ivermectin^a	1 (4)	2.75 ± 0.96	6.25 ± 1.50	(22.43)	(44.29 ± 5.15)**
DEC-C^a	25 (6)	2.60 ± 0.55	6.60 ± 1.14	9.20 ± 1.48	0.60 ± 0.89
DEC-C^a	25 (6)	2.60 ± 0.55	6.60 ± 1.14	(22.03)	(7.86 ± 11.41)
Control (Vehicle treated)	– (5)	3.40 ± 1.97	8.40 ± 2.07	11.80 ± 0.45	0.40 ± 0.55
Control (Vehicle treated)	– (5)	3.40 ± 1.97	8.40 ± 2.07	11.80 ± 0.45	(5.71 ± 7.82)

^aReference drugs; DEC-C: Diethylcarbamazine-Citrate

^bOne animal showed presence of live adult worms but not dead/calcified worms

**P < 0.01 (ivermectin vs Control/DEC/K004); ***P < 0.001 (K003 vs control/K004/ivermectin/DEC; A001 vs control/K003/K004/ivermectin/DEC)