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. 2016 Jun 1;10:139. doi: 10.3389/fncel.2016.00139

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Copyright © 2016 Villarreal, Rosciszewski, Murta, Cadena, Usach, Dodes-Traian, Setton-Avruj, Barbeito and Ramos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ischemia-derived astrocyte phenotype persistence requires gamma secretase activity. (A) Representative images of eGFP-IDA cell cultures of 7 DIV showing the phenotypical transformation from the fusiform morphology to the stellated morphology induced by the 48 h-treatment with the gamma secretase inhibitor DAPT; control cells received vehicle; bar = 25 μm. (B) Relative abundance of GFAP immunostained astrocytes in the eGFP IDA cultures after treatment with different DAPT concentrations. Statistical significance was confirmed with the non-parametric Kruskal–Wallis test and Dunn’s Multiple Comparison Test (*p < 0.05).