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. 2016 May 26;9:3137–3146. doi: 10.2147/OTT.S102338

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© 2016 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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YAP1 knockdown promoted apoptosis of EC cell lines.

Notes: (A and C) Both EC109 and TE10 YAP1-knockdown cells (sh-YAP1) had significantly increased apoptosis compared to controls (sh-control). (B and D) The expression levels of Bcl-2 protein were significantly lower in YAP1-knockdown EC109 and TE10 cells (sh-YAP1) than those in controls (sh-control), while the expression levels of Bax protein were increased. ***P<0.001.

Abbreviations: EC, esophageal cancer; sh-YAP1, short-hairpin RNA expression vector targeting YAP1; PI, propidium iodide; FITC, fluorescein isothiocyanate.