Table 6.

Dosage and administration of SGLT2 inhibitors according to renal function (eGFR)

Canagliflozin4	Assess renal function before initiating canagliflozin therapy Canagliflozin is limited to 100 mg once daily in patients who have an eGFR of 45 to <60 mL/min/1.73 m2 Do not initiate canagliflozin if eGFR is <45 mL/min/1.73 m2 Discontinue canagliflozin if eGFR falls persistently below 45 mL/min/1.73 m2
Dapagliflozin5	Assess renal function before initiating dapagliflozin therapy Do not initiate if eGFR <60 mL/min/1.73 m2 Discontinue dapagliflozin if eGFR falls persistently below 60 mL/min/1.73 m2
Empagliflozin6	Assess renal function before initiating empagliflozin therapy Do not initiate empagliflozin if eGFR is <45 mL/min/1.73 m2 Discontinue empagliflozin if eGFR falls persistently below 45 mL/min/1.73 m2

Abbreviation: eGFR, estimated glomerular filtration rate.