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. 2016 May 15;30(10):1187–1197. doi: 10.1101/gad.278887.116

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© 2016 Schibler et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — The set1G951S mutant requires the SAC and Cdc20 inhibition for benomyl resistance. (A) An illustration of Cdc20 associated with the APC complex in both an active and an inactive state. Mad2 and Mad3 bind to Cdc20 to inhibit the ubiquitination of APC substrates. (B–D) Serial fivefold dilution assay of yeast strains with the indicated genotypes grown on normal YPD plates (YPD) or plates containing 30 µg/mL benomyl for 2 d at 30°C.