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A model showing that methylated H3K4 binds to C-Mad2. An H3 sequence required for Mad2 binding, which is similar to the Mad2-binding consensus sequence, is underlined. Our in vivo and in vitro data indicate that H3K4me acts as a negative regulator of the SAC through direct binding of methylated H3K4 to an active C-Mad2, thereby limiting C-Mad2–Cdc20 interactions.
