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. 2016 May 15;30(10):1211–1224. doi: 10.1101/gad.280685.116

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© 2016 Tsabar et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — The two repairable DSB system. (A) Schematic of the two-DSB system. The top panel describes the GC assay (slower to repair), while the bottom panel describes the SSA repair construct (faster to repair). (B) Viability of the wild type and the cac1Δ, asf1Δ, and asf1Δ cac1Δ mutants in the ectopic GC (YJK17) and ectopic GC+SSA (YFA01) backgrounds. n ≥ 3. (**) P < 0.005, calculated relative to wild type. (C) Schematic of YMT170. After HO induction, repair requires a 25-kb resection and is executed through SSA, as in strain YMV080 (Vaze et al. 2002). Strain YMT170 is similar to YMV080, but the NAT cassette has been switched with HPH. (D) Viability of wild type (YMT170) and asf1Δ (YMT169).