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The effect of the histone H3 handoff pathway on recovery when the DNA damage checkpoint is activated by two DSBs. (A) Epistasis analysis of YLK03 (rtt101Δ) and YFA06 (rtt109Δ) with asf1Δ and cac1Δ. n ≥ 3. (**) P < 0.005, calculated relative to wild type. (B) Adaptation assay in rtt109Δ and rtt101Δ. Adapted cells were counted at 24 h. Error bars indicate ranges. n = 2. (C) The viability of wild type, mad2Δ, rtt101Δ, and rtt101Δ mad2Δ. n ≥ 3. (**) P < 0.005.
