-
A–D
Albumin (A), Cluster of differentiation 31 (B), desmin (C) and EGF‐like module‐containing mucin‐like hormone receptor‐like 1 (D) mRNA expression were measured from fractionated parenchymal hepatocytes (Hepas) as well as non‐parenchymal cells (NP) from C57Bl/6J mice fed ad libitum (fed) or fasted for 24 h (fasted) (n = 3/group).
-
E
Male C57Bl/6J mice with (AAV‐G45b miR) or without (AAV‐NC miR) liver/hepatocyte‐restricted GADD45β silencing were fed or fasted for 24 h (n = 6/group). Liver Gadd45b mRNA expression was measured.
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F–H
Male GADD45β+/+ (WT) or GADD45β−/− (KO) mice fasted for 24 h (fasted) with (AD‐G45b OE) or without (AD‐NC) liver‐restricted Gadd45b over‐expression (n = 7–8/group). Liver mRNA expression of Gadd45b (F). Serum non‐esterified fatty acids (G) and triglycerides (H) were measured.
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I–K
Male C57Bl/6J mice with (AAV‐G45b miR) or without (AAV‐NC miR) liver/hepatocyte‐restricted GADD45β silencing were chronically fed a normal‐fat diet (NFD) or high ‐fat diet (HFD) and were sacrificed in the ad libitum fed state (n = 6–8/group). Body (I), liver (J) and perigonadal white adipose tissue (K) masses.
Data information: Data are mean ± SEM. Effect of genotype, *
P < 0.05, **
P < 0.01, ***
P < 0.001. Effect of nutritional state:
#
P < 0.05,
##
P < 0.01,
###
P < 0.001. The statistical test used and respective
P‐value outputs can be found in
Appendix Table S1.
