Table 1.

Results of T-Cell Studies at Week 60 (ITT & CR-sensitive)^*

		Control Mean (SD)	Intervention Mean (SD)	p value#
Lymphocyte Cytokine Expression (mRNA copies)		N=15	N=16
(IL-13/UBE)	CR3, 48 hr	0.009 (0.011)	0.010 (0.002)	0.241
	CR10, 24hr	0.008 (0.007)	0.004 (0.002)	0.321
	CR10, 48 hr	0.009 (0.009)	0.020 (0.024)	0.231
	CR10, 72 hr	0.012 (0.009)	0.014 (0.013)	11
	CR30, 24hr	0.009 (0.008)	0.007 (0.004)	0.861
	CR30, 48 hr	0.012 (0.012)	0.010 (0.008)	0.541
	CR30, 72 hr	0.012 (0.008)	0.016 (0.013)	0.671
	mABS, 24 hr	0.083 (0.068)	0.044 (0.028)
(IFNγ/UBE)	CR3, 48 hr	0.14 (0.15)	0.18 (0.19)	0.691
	CR10, 24hr	0.32 (0.65)	0.31 (0.45)	0.371
	CR10, 48 hr	0.21 (0.29)	0.26 (0.43)	0.771
	CR10, 72 hr	0.19 (0.19)	0.14 (0.08)	11
	CR30, 24hr	0.33 (0.60)	0.28 (0.47)	0.721
	CR30, 48 hr	0.19 (0.25)	0.13 (0.22)	0.561
	CR30, 72 hr	0.13 (0.10)	0.09 (0.08)	0.251
	mABS, 24 hr	2.12 (1.53)	4.05 (4.25)
Treg Cells		N=15	N=17
CD3+CD4+CD25+CD127-FoxP3+ (Abs cells/μL)		27 (18)	21 (14)	0.261
CD3+CD4+CD25+CD127-FoxP3+ (%)		3.2 (1.6)	2.6 (1.0)	0.241
CD3+CD4+CD25+CD127-FoxP3+ of CD3+CD4+ (%)		6.9 (2.7)	5.9 (1.7)	0.291
CD3+CD4+CD25+ FoxP3+ (Abs cells/μL)		31 (19)	26 (16)	0.421
CD3+CD4+CD25+ FoxP3+ (%)		3.7 (1.6)	3.2 (1.3)	0.421
CD3+CD4+CD25+ FoxP3+ of CD3+CD4+ (%)		8.0 (2.6)	7.5 (2.1)	0.541

^*Study participants from the Chicago and Cleveland sites.

^¶Cockroach sensitive is defined as a German Roach Wheal size of ≤3mm from the Allergen Skin Test.

^#Similar results were found for CR-sensitive and CR-insensitive subjects combined as well as in the Per-Protocol Population.

¹Wilcoxon Test