Table 3. Meta-analysis of association of SCARB1 P376L variant with CHD.
CHD cases and healthy controls across the CARDIoGRAM Exome Consortium and CHD Exome+ Consortium were genotyped for the SCARB1 P376Lvariant by using the exome array. BioVU, Vanderbilt University Medical Center Biorepository; BHF, British Heart Foundation; GoDARTS-CAD, Genetics of Diabetes and Audit Research Tayside Study; MHI, Montreal Heart Institute; North German, German North Coronary Artery Disease Study; Ottawa, Ottawa Heart Study; PAS, Premature Atherosclerosis Study—Academic Medical Center—Amsterdam; Penn, University of Pennsylvania CHD Cohort; South German, German South Coronary Artery Disease Study; WHI-EA, Women’s Health Initiative—American Cohort; CCHS, Copenhagen City Heart Study; CIHDS/CGPS, gen Ischemic Heart Disease Study/Copenhagen General Population Study; EPIC-CVD, European Prospective Investigation into Cancer and Nutrition— Cardiovascular Disease Study; MORGAM, MOnica Risk, Genetics, Archiving and Monograph Project; PROSPER, Prospective Study of Pravastatin in the Elderly at Risk Study; WOSCOPS, West of Scotland Coronary Prevention Study. The association of the P376L variant with CHD cases was determined using a Mantel-Haenszel fixed-effects Meta-analysis; results were odds ratio = 1.79; P = 0.018.
| Consortium or study cohort | P376L carriers | Total | Frequency | |||
|---|---|---|---|---|---|---|
| Cases | Controls | CHD cases | Controls | Cases | Controls | |
| CARDIoGRAM Exome Consortium | ||||||
| BioVU | 6 | 10 | 4587 | 16546 | 0.0013 | 0.0006 |
| BHF | 1 | 0 | 2833 | 5912 | 0.0004 | 0 |
| GoDARTS-CAD | 1 | 0 | 1568 | 2772 | 0.0006 | 0 |
| MHI | 0 | 4 | 2483 | 8085 | 0 | 0.0005 |
| North German | 0 | 1 | 4464 | 2886 | 0 | 0.0004 |
| Ottawa | 0 | 1 | 1024 | 2267 | 0 | 0.0004 |
| PAS | 1 | 1 | 728 | 808 | 0.0014 | 0.0012 |
| Penn | 3 | 0 | 683 | 156 | 0.0044 | 0 |
| South German | 4 | 0 | 5255 | 2921 | 0.0008 | 0 |
| WHI-EA | 8 | 29 | 2860 | 14929 | 0.0028 | 0.0019 |
| CHD Exome+ Consortium | ||||||
| CCHS | 1 | 1 | 2020 | 6087 | 0.0003 | 0.0001 |
| CIHDS/CGPS | 4 | 3 | 8079 | 10367 | 0.0003 | 0.0001 |
| EPIC-CVD | 4 | 2 | 9810 | 10970 | 0.0002 | 0.0001 |
| MORGAM | 0 | 0 | 2153 | 2118 | 0 | 0 |
| PROSPER | 1 | 0 | 640 | 638 | 0.0008 | 0 |
| WOSCOPS | 0 | 0 | 659 | 687 | 0 | 0 |
| Total | 34 | 52 | 49846 | 88149 | 0.00068 | 0.00059 |