Table 1.
Results of comparison of frequency of C-allele of SLCO1B1, Russian and Sakha (Yakutia) versus published data
| Population | n | TT genotype | TC genotype | CC genotype | T allelea | C allelea | Comparison with Russian | Comparison with Sakha (Yakutia) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Chi-squared | P | OR (95% CI) | Chi-squared | P | OR (95% CI) | |||||||
| Russian Federation, Russians | 1,071 | 665 (62%) | 346 (32%) | 60 (6%) | 1,676 (78%) | 466 (22%) | – | – | – | 8.9 | 0.0028 | 2.2 (1.32–3.70) |
| Russian Federation, Sakha (Yakutia) | 76 | 62 (82%) | 11 (14%) | 3 (4%) | 135 (89%) | 17 (11%) | 8.9 | 0.0028 | 0.45 (0.27–0.76) | – | – | – |
| Brazil11 | 216 | 152 (71%) | 59 (27%) | 5 (2%) | 363 (84%) | 69 (16%) | 7.1 | 0.0078 | 0.68 (0.52–0.90) | 1.69 | 0.19 | 1.5 (0.86–2.66) |
| China12 | 272 | 205 (75%) | 62 (23%) | 5 (2%) | 472 (87%) | 72 (13%) | 19.3 | <0.0001 | 0.55 (0.42–0.72) | 0.28 | 0.59 | 1.2 (0.69–2.13) |
| China13 | 363 | 256 (71%) | 95 (26%) | 12 (3%) | 607 (83%) | 119 (17%) | 9.4 | 0.002 | 0.70 (0.56–0.88) | 2.2 | 0.136 | 1.56 (0.91–2.68) |
| China14 | 140 | 111 (79%) | 27 (19%) | 2 (2%) | 249 (89%) | 31 (11%) | 16.8 | <0.0001 | 0.45 (0.30–0.66) | 0.0013 | 0.97 | 0.99 (0.53–1.85) |
| China15 | 373 | 281 (75%) | 82 (22%) | 10 (3%) | 644 (86%) | 102 (14%) | 22.6 | <0.0001 | (0.45–0.72) | 0.48 | 0.49 | 1.26 (0.73–2.17) |
| France16 | 724 | 519 (72%) | 193 (26.5%) | 12 (1.5%) | 1,231 (85%) | 217 (15%) | 25.6 | <0.0001 | 0.63 (0.53–0.75) | 1.3 | 0.25 | 1.4 (0.83–2.37) |
| Japan17 | 64 | 44 (73%) | 20 (27%) | 0 (0%) | 108 (84%) | 20 (16%) | 2.4 | 0.12 | 0.66 (0.41–1.08) | 0.83 | 0.36 | 1.47 (0.73–2.95) |
Note:
a
Number (allele frequency).