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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Mutat Res Rev Mutat Res. 2016 Mar 31;768:46–52. doi: 10.1016/j.mrrev.2016.03.005

Fig. 3.

Fig. 3

Model for leukemogenesis mediated by aberrant DOT1L H3K79 methylation. (A) MLL gene undergoes chromosomal translocations and fusion with a number of fusion proteins such as AF9, AF10, and hDot1L. This leads to mistargeting of hDot1L to MLL-regulated genes such as Hox genes. Aberrant H3K79 methylation and the subsequent activation of the target genes result in leukemic transformation. (B) Inhibition of hDot1L HMTase activity with small molecules would prevent aberrant H3K79 methylation and inhibition of MLL-related leukemogenesis.