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. 2016 Jun 1;11(6):e0156702. doi: 10.1371/journal.pone.0156702

Table 4. Overview of literature of regulation by methylation of important transcription factors and inflammatory genes.

Gene/protein name Regulated by methylation Reference
ELK1 Yes, downregulated in cancer [23]
SRF Yes, downregulated in cancer [23]
CREB To the best of our knowledge, there are no data available
IL-6 Promoter demethylation after ADC, LPS has no additional effect on demethylation, one position: nt-1099 is less methylated in PBMCs of patients with rheumatoid arthritis [29,30]
IL-8 7.0-fold increased expression after LPS with ADC-TSA (trichostatin A) treatment [24]
IL-6 2.5-fold increased expression after LPS with ADC-TSA (trichostatin A) treatment [24]
TNF-α 1.6-fold increased expression after LPS with ADC-TSA (trichostatin A) treatment [24]
TLR-2 Hypomethylation is associated with increased proinflammatory response [25]
TLR-4 TLR-4 hypermethylation causes low response to LPS [26]
TLR-2, TLR-4, lipopolysaccharide-binding protein (LBP) and haptoglobin (HP) Promoters are opened after LPS, which may be caused by demethylation [27]