Table 2. Expression of putative PAX8 target genes in the 36 PTCs stratified by ATA risk and BRAF mutational status.
| Gene | *ATA risk | **BRAF status | |||
|---|---|---|---|---|---|
| Low Risk (n = 17) | Intermediate Risk (n = 19) | BRAF–wt (n = 21) | BRAFV600E (n = 15) | ||
| Upregulated genes in Pax8 knock-out mice§ | |||||
| CA3 | 1±0.556 | 0.930±0.550 | 1±0.535 | 0.956±0.577 | |
| FSTL1 | 1±0.824 | 1.376±1.067 | 1±0.857 | 0.926±0.724 | |
| GPC3 | 1±1.236 | 0.719±1.092 | 1±1.178 | 0.653±1.011 | |
| LCN2 | 1±1.234 | 1.637±3.033 | 1±1.103 | 1.985±3.495 | |
| LGALS1 | 1±1.329 | 1.293±1.112 | 1±1.172 | 0.903±0.858 | |
| LUM | 1±3.374 | 0.417±0.531 | 1±1.635 | 2.524±8.240 | |
| SCD1 | 1±0.904 | 0.772±0.573 | 1±1.057 | 1.707±1.246 | |
| Downregulated genes in Pax8 knock-out mice§ | |||||
| ATP1B1 | 1±0.447 | 0.870±0.412 | 1±0.440 | 1.065±0.509 | |
| KCNIP3 | 1±0.649 | 0.944±1.265 | 1±1.000 | 0.531±0.448 | |
| NFKBIA | 1±1.307 | 0.805±0.736 | 1±1.125 | 0.580±0.602 | |
| PRLR | 1±2.047 | 0.571±0.771 | 1±1.559 | 0.178±0.126 | |
mRNA levels are expressed as mean ± SD.
* mRNA levels in the ATA risk intermediate group are expressed as relative quantity with respect to the ATA risk low group, arbitrarily considered as 1.0.
** mRNA levels in samples with the BRAFV600E mutation are expressed as relative quantity with respect to BRAF-wt group, arbitrarily considered as 1.0.
All mRNA values indicated in this table have p values >0.05 when compared to respective control groups, as assessed by Mann Whitney test.
wt, wild type.
§ Data from Marotta et al., 2014.