Table 10.
Percentage Distribution and Logistic Regression for AAA‐Associated Inflammation Risks
| AAA‐Associated Inflammation Risk Score | ||||
|---|---|---|---|---|
| 0 | 1 | 2 | 3 | |
| Control (n=970) | 25.5% | 46.6% | 21.5% | 4.4% |
| AAA (n=442) | 6.4% | 28.6% | 44.8% | 20.2% |
| AAA OR | 0.43 (0.27–0.68)‡ | 1 | 3.5 (2.7–4.7)† | 7.8 (5.1–12.1)† |
| Adjusted ORa | 0.36 (0.20–0.64)‡ | 1 | 3.5 (2.4–5.1)† | 5.3 (3.1–9.1)† |
| Adjusted ORa | 0.36 (0.20–0.64)‡ | 1 | 3.8 (2.7–5.4)† | |
| Adjusted ORa | 1 | 4.8 (3.5–6.7)† | ||
The combined AAA inflammation marker risk score assigned 1 point for each of the following: hsCRP >2.5 mg/L, RANTES <14 500 pg/mL, and eotaxin >125 pg/mL (scoring each individual between 0 and 3). AAA‐associated inflammation risk scores were significantly higher in the AAA group (χ2, P<0.0001). Using an AAA inflammation score of 1 (the most common score among controls) as the reference value, logistic regression suggested a protective association for those with a 0 score and a staged positive risk association with higher (2 or 3) scores. AAA indicates abdominal aortic aneurysm; hsCRP, high sensitivity C‐reactive protein; OR, odds ratio; RANTES, regulated on activation, normal T‐cell expressed and secreted.
Adjusted for age, sex, history of ischemic heart disease, smoking (pack‐years), and sample storage time.
† P<0.0001; ‡ P<0.0005.