Table 2.
Overview of the Genotype and Allele Frequencies of NLRP3 Downstream Single Nucleotide Polymorphisms (SNPs) in Patients With Myocardial Infarction and Healthy Controls in the FIA Cohort
| SNP | Genotype | Patients | Controls | Odds Ratio (95% CI) | P Value |
|---|---|---|---|---|---|
| Genotype frequencies | |||||
| rs4353135 | n=459 (%) | n=860 (%) | |||
| TT | 237 (52) | 483 (56) | 1 | ||
| GG | 29 (6) | 63 (7) | 0.93 (0.58–1.49) | 0.78 | |
| GT | 193 (42) | 31 (37) | 1.25 (0.98–1.58) | 0.06 | |
| rs4266924 | n=490 (%) | n=902 (%) | |||
| AA | 380 (78) | 708 (79) | 1 | ||
| GG | 4 (0.8) | 10 (0.1) | 1.3 (0.42–4.36) | 0.61 | |
| AG | 106 (21) | 184 (21) | 1.4 (0.44–4.70) | 0.54 | |
| rs6672995 | n=491 (%) | n=901 (%) | |||
| GG | 355 (72) | 640 (71) | 1 | ||
| AA | 13 (3) | 23 (3) | 1.0 (0.51–2.03) | 0.95 | |
| AG | 123 (25) | 238 (26) | 0.93 (0.72–1.20) | 0.58 | |
| rs10733113 | n=432 (%) | n=802 (%) | |||
| GG | 320 (74) | 592 (74) | 1 | ||
| AA | 6 (1) | 12 (1) | 0.92 (0.34–2.48) | 0.87 | |
| AG | 106 (25) | 198 (25) | 0.99 (0.75–1.30) | 0.94 | |
| Allele frequencies | |||||
| rs4353135 | n=918 (%) | n=1720 (%) | |||
| T | 667 (73) | 1280 (74) | 1 | ||
| G | 251 (27) | 440 (26) | 1.0 (0.91–1.3) | 0.32 | |
| rs4266924 | n=980 (%) | n=1804 (%) | |||
| A | 866 (88) | 1600 (89) | 1 | ||
| G | 114 (12) | 204 (11) | 0.9 (0.7–1.23) | 0.79 | |
| rs6672995 | n=982 (%) | n=1802 (%) | |||
| G | 833 (85) | 1518 (84) | 1 | ||
| A | 149 (15) | 284 (16) | 0.95 (0.7–1.18) | 0.68 | |
| rs10733113 | n=864 (%) | n=1604 (%) | |||
| G | 746 (86) | 1382 (86) | 1 | ||
| A | 118 (14) | 222 (14) | 0.9 (0.7–1.25) | 0.89 | |
FIA indicates First‐ever myocardial Infarction study in Ac‐county; NLRP3, NLR Family, Pyrin Domain Containing 3; SNPs, Single Nucleotide Polymorphisms.