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. 2016 May 5;5(5):e003046. doi: 10.1161/JAHA.115.003046

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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MitoTEMPO effects on relaxation in isolated cardiomyocytes. A and B, Representative normalized sarcomere contraction and relaxation traces in control (black) vs HFD mice (red) (A); HFD mice vs mitoTEMPO‐treated mice (blue) (B). Bar represents 0.2 seconds. C, Basal diastolic sarcomere length. D, Relaxation constant, τ. E, time to 50% relaxation. F, Fractional shortening. N=4 mice in control, N=6 mice in the HFD and mitoTEMPO groups. Five to 10 myocytes were studied from each mouse. Total cardiomyocytes are indicated in each bar graph. *P<0.05. HFD indicates high‐fat diet; MitoTEMPO, 2‐(2,2,6,6‐tetramethyl‐piperidin‐1‐oxyl‐4‐ylamino)‐2‐oxoethyl‐triphenylphosphonium chloride).