Table 3.
Adjusteda Prevalence Ratios (PRs) for the Highest Quartile of Galectin‐3 (Unweighted N=1809); Overall and Stratified by Race
| Overall | White (N=1375) | Black (N=434) | |
|---|---|---|---|
| PR (95% CI) | PR (95% CI) | PR (95% CI) | |
| Age, per 10 y | 1.63 (1.34–1.97) b | 1.80 (1.41–2.30) b | 1.26 (0.94–1.69) |
| Female (vs male) | 1.32 (1.07–1.62) b | 1.32 (1.03–1.68) b | 1.37 (0.95–2.00) |
| Black (vs white) | 1.37 (1.11–1.70) b | — | — |
| Body mass index, kg/m2 | |||
| 25–30 (vs <25) | 1.03 (0.78–1.35) | 1.05 (0.77–1.43) | 0.96 (0.56–1.64) |
| ≥30 (vs <25) | 1.22 (0.92–1.60) | 1.16 (0.84–1.61) | 1.29 (0.77–2.17) |
| Cigarette smoking | |||
| Current smoker (vs never) | 0.90 (0.61–1.33) | 0.85 (0.51–1.41) | 0.91 (0.49–1.69) |
| Former smoker (vs never) | 0.94 (0.76–1.16) | 0.97 (0.76–1.25) | 0.84 (0.58–1.22) |
| High total cholesterol (≥200 mg/dL), yes/no | 1.19 (0.96–1.48) | 1.31 (1.01–1.69) | 0.91 (0.64–1.30) |
| Low HDL cholesterolc, yes/no | 1.31 (1.07–1.61)b | 1.28 (1.00–1.63) | 1.35 (0.94–1.94) |
| Hypertensiond, yes/no | 1.07 (0.82–1.39) | 1.11 (0.81–1.51) | 0.94 (0.60–1.48) |
| Diabetese, yes/no | 1.05 (0.86–1.29) | 1.22 (0.95–1.56) | 0.74 (0.53–1.05) |
| Low eGFRf, yes/no | 2.34 (1.92–2.86)b | 2.35 (1.85–3.00)b | 2.44 (1.75–3.39)b |
ARIC indicates Atherosclerosis Risk in Communities; eGFR, estimated glomerular filtration rate; HDL, high‐density lipoprotein cholesterol.
Poisson model adjusted for all variables listed above and are weighted, where the number observed to be at risk (N=1809) is reweighted to reflect the entire available ARIC cohort (N=4731) using a stratified sampling design.
P<0.05.
Low HDL cholesterol is defined as <40 mg/dL for men and <50 mg/dL for women.
Hypertension is defined as diastolic blood pressure ≥90 mm Hg, systolic blood pressure ≥140 mm Hg, or antihypertensive medication use.
Diabetes is defined as self‐report doctor‐diagnosed diabetes or medication use, fasting glucose ≥126 mg/dL, or hemoglobin A1c ≥6.5%.
Low eGFR is defined as <60 mL/min per 1.73 m2.