Table 3.

Characteristics of Studies that Presented Adjusted Odds Estimates

First Author (Year)	No. of Patients taking AP medications, N	No. of Controls, N	Adjusted Estimates	Stratification by OTT	Stratification by AP Agents	Stratification by Outcome Definitions	Adjusting Variables
Xian29 (2016)	22 813	20 221	sICH, good functional outcome, mortality	0–3 h	A, C, AC, AD	mRS 0–1, mRS 0–2	G, X, OTT, APM, HC, HS
Pan25 (2015)	157	951	sICH, mortality	NA	A, AC	NINDS, ECASS II, SITS‐MOST	NA
Meurer24 (2013)	388	442	sICH	NA	NA	NA	G, S, N, OTT
Dorado19 (2010)	72	163	sICH	NA	NA	NA	X, E, HC, PVD, R
Diedler18 (2010)	3782	7954	sICH, good functional outcome, mortality	NA	A, C, AC, AD	NINDS, ECASS II, SITS‐MOST/mRS 0–1, mRS 0–2	NA
Cucchiara16 (2009)	337	628	sICH, good functional outcome,	NA	Single, double	NA	G, N, SBP, DBP, HTN, SG, HC, HS, ASP
Uyttenboogaart13 (2008)	89	212	sICH, good functional outcome	0–3 h	NA	NA	G, N, SG, R, SBP, HTN

AP indicates antiplatelet; OTT, onset‐to‐treatment time; sICH, symptomatic intracranial hemorrhage; A, aspirin; C, clopidogrel, AC, aspirin‐clopidogrel; AD, aspirin‐dipyridamole; mRS, modified Rankin Scale; G, age; X, sex; APM, type of antiplatelet medication; HC, history of coronary heart disease; HS, history of stroke/ transient ischemic attack; NA, not available; NINDS, National Institute of Neurological Disorders and Stroke rt‐PA Stroke Study Group2; ECASS II, Second European‐ Australasian Acute Stroke Study3; SITS‐MOST, Safe Implementation of Thrombolysis in Stroke‐Monitoring Study4; S, tobacco smoking; N, National Institute of Health Stroke Scale; E, history of ethanol abuse; PVD, history of peripheral vascular disease; R, prehospital radiology results; SBP, systolic blood pressure; DBP, diastolic blood pressure; HTN, history of hypertension; SG, serum glucose; ASP, the Alberta Stroke Program Early CT Score (ASPECTS).