Table 1.
Population Characteristics
| Overall | CMET+ | CMET− | P Valuea | |
|---|---|---|---|---|
| Clinical | ||||
| Age, y | 58±15 | 60±14 | 57±16 | 0.14 |
| Male sex | 60% (36) | 56% (18) | 64% (18) | 0.77 |
| Disease duration, y | 3.6±3.6 | 3.8±3.8 | 3.4±3.3 | 0.79 |
| Cancer diagnosis | ||||
| Sarcoma | 23% (14) | 22% (7) | 25% (7) | — |
| Skin cancer/melanoma | 17% (10) | 16% (5) | 18% (5) | — |
| Gastrointestinal | 17% (10) | 16% (5) | 18% (5) | — |
| Lung | 7% (4) | 6% (2) | 7% (2) | — |
| Head and neck | 7% (4) | 6% (2) | 7% (2) | — |
| Disease extent (No. of organs involved) | 3.6±2.1 | 4.4±2.0 | 2.7±1.9 | 0.03b |
| Excluding cardiac involvement | 3.1±2.0 | 3.4±2.0 | 2.7±1.9 | 0.17 |
| Anticancer regimen | ||||
| Chemotherapy | ||||
| Alkylating agent | 27% (16) | 34% (11) | 18% (5) | 0.13 |
| Platinum | 33% (20) | 41% (13) | 25% (7) | 0.11 |
| Antimetabolite | 25% (15) | 31% (10) | 18% (5) | 0.23 |
| Anthracycline | 18% (11) | 22% (7) | 14% (4) | 0.38 |
| Topoisomerase inhibitor | 18% (11) | 16% (5) | 21% (6) | 1.00 |
| Biologic agents | 40% (24) | 34% (11) | 46% (13) | 0.34 |
| Radiation therapy | ||||
| Mediastinal radiation | 8% (5) | 9% (3) | 7% (2) | 1.00 |
| Nonmediastinal radiation | 25% (15) | 28% (9) | 21% (6) | 1.00 |
| Comorbidities | ||||
| Coronary artery disease | 8% (5) | 3% (1) | 14% (4) | 0.38 |
| Hypertension | 37% (22) | 31% (10) | 43% (12) | 0.58 |
| Diabetes mellitus | 10% (6) | 6% (2) | 14% (4) | 0.69 |
| Hypercholesterolemia | 20% (12) | 9% (3) | 32% (9) | 0.07 |
| Tobacco use | 33% (20) | 31% (10) | 36% (10) | 1.00 |
| Cardiac morphology and function | ||||
| Left ventricle | ||||
| Ejection fraction, % | 62±10 | 64±9 | 60±11 | 0.40 |
| End‐diastolic volume, mL | 117±39 | 110±38 | 125±39 | 0.07 |
| End‐systolic volume, mL | 45±20 | 41±19 | 50±21 | 0.07 |
| Myocardial mass, g | 122±66 | 129±84 | 114±38 | 0.72 |
| Right ventricle | ||||
| Ejection fraction, % | 52±11 | 51±12 | 53±9 | 0.34 |
| End‐diastolic volume, mL | 137±52 | 130±46 | 146±59 | 0.14 |
| End‐systolic volume, mL | 68±31 | 65±31 | 71±33 | 0.29 |
| Atria | ||||
| Left atrial area, cm2 | 20±6 | 19±7 | 21±6 | 0.11 |
| Right atrial area, cm2 | 21±7 | 20±6 | 22±8 | 0.30 |
a
Matching not possible in 4 patients (cerebellar hemipericytoma, adrenal, renal cell carcinoma [n=2]) because of nonequivalent primary cancer diagnosis among control patients with stage IV cancer (cardiac metastasis negative [CMET]−) undergoing cardiac magnetic resonance; P‐values reflect comparisons between matched cases and controls (CMET+ n=28; controls n=28).
b
P<0.05.