Table 1.
Blood Parameters of Nontransplanted Lewis (LEW/OrlRj) Rats After 28 Days of Intravenous Treatment With Saline or RNase A
| Blood Parameters | Treatment Groups | ||
|---|---|---|---|
| Control (Saline) | RNase A (50 μg/kg) | RNase A (1000 μg/kg) | |
| Creatinine, mg/dL | 0.7±0.2 | 0.6±0.0 | 0.6±0.1 |
| Urea, mg/dL | 54±3 | 41±2 | 47±3 |
| GPT/ALT, U/L | 64±4 | 44±6 | 54±3 |
| Leukocytes, K/μL | 9.8±1.8 | 9.2±0.9 | 10±0.9 |
| Hemoglobin, g/dL | 14.7±1.1 | 16.3±0.2 | 15.4±0.8 |
All parameters were in normal range compared to blood parameters of 10‐week‐old Lewis (LEW/OrlRj) rats (normal values provided by Janvier Labs [http://www.janvier-labs.com/tl_files/_media/images/FICHE_RESEARCH_MODEL_LEWIS.pdf, Technical Sheet 2013‐06‐ENG‐RM‐08, accessed: January 17, 2016]). Data represent mean±SD; n=3 in each group; RNase A, ribonuclease A; GPT/ALT, glutamate‐pyruvate transaminase or alanine transaminase, respectively.